MST43

The 43rd International Conference of the Microscopy Society of Thailand
June 8 - 11, 2026, The 80th Anniversary of Kasetsart University Hall, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom, Thailand



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MST43 Speaker Detail



Prof.Dr.Badrul Hisham Yahaya
Invited Speaker
Abstract Title: Intelligent stem cells for precision oncotherapy
Session: Biological Science
From: Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Malaysia

Biography

  1. Name: Prof Dr Badrul Hisham Yahaya 
  2. Date of Birth and Nationality:4 April 1980 and Malaysian 
  3. Work Address: Department of Biomedical Sciences, Pusat Kanser Tun Abdullah Ahmad Badawi, Universiti Sains Malaysia 13200 Bertam, Kepala Batas, Penang  Tel. No.: 04-562 2539 Fax No.: -  Mobile Phone No.: 012-9754067 
    E-mail Address: badrul@usm.my 
  4. Academic Qualifications: BSc (Genetics with Hons) UKM, MSc (Human Genetics) USM, PhD (Regenerative Medicine) University of Edinburgh, Scotland 
  5. Brief Career History: 
  • June 2010 - Dec 2015 : Senior Lecturer 
  • Jan 2016 - 2025 :  Associate Professor 
  • March 2013 - Dec 2015 : Head, Regenerative Medicine Cluster 
  • August 2017 - Sept 2017 : Head, Regenerative Medicine Cluster
  • Jan 2019 - Dec 2021 : Director, Animal Research & Service Centre (ARASC), USM,
  • June 2022 - present : Head, Breast Cancer Translational Research Program (BCTRP@IPPT) 
  • Jan 2025 - present : Deputy Director (Research & Networks) 
  • April 2025 - present : Professor
        6. Field(s) of Specialization: Stem Cell Biology & Regenerative Medicine
        7. Current Research Areas/Topics: Cell Therapy, Tissue Engineering, Organoids, Cancer Stem Cells
        8. Google Scholar: D90_Q4UAAAAJ
                                      ORCID : 0000-0002-3295-9676
                                      Scopus ID : 53872327800
 
External Research Funding: 
 
1. 3D-printed tracheal scaffold as an alternative source for tracheal replacement - NSGF, Japan (Int)
2. Honey-Based Inhaler And Its Regenerative Potential In Animal Model Of Asthma - Science Fund, MOSTI (Nat)
3. The effect of bioactive and bioresorbable ceramic/polymer layer scaffold on bone-derived progenitor and stem cell behaviours - TRGS, MoHE (Nat)
4. The roles of ALDH1A1 and RARB1 in regulating the tumorigenicity of the non-small cell lung cancer (NSCLC) stem cells - FRGS, MoHE (Nat) Format of the External Examiner’s CV
5. The effect of umbilical cord mesenchymal stem cells derived extracellular vesicles on COPD - Cryocord Sdn Bhd (Indutry)
6. The effect of smoking on the stemness capabilities of lung stem cells in mice model of COPD - FRGS, MoHE (Nat)
7. The 3D-TechTra as Bioengineered Scaffold for Tracheal Tissue Replacement - PRGS, MoHE (Nat)
8. The preclinical evaluation of mesenchymal stem cell based of antineoplastic nano-drug delivery for tumour-targeted therapy in breast cancer - Matching Grant USM - Cryocord Sdn Bhd (Univ)
9. The development of an antineoplastic nano-drug delivery system of mesenchymal stem cell based on an artificial signal-driven network for tumor-targeted therapy in breast cancer - Cryocord Sdn Bhd (Industry)
10. Investigating Airway Regeneration Following Cigarette-Induced airway inflammation in the Absence of Alveolar Type-2 (AT2) Cells –In vitro model system - Matching Grant USM-RIKEN (Univ)
 
University Funding
1. Establishment of Aerosol-based Cell Delivery Technique to Study the Effect of Airway Epithelial Stem Cell-Like Cells Regeneration in Animal Models of Acute Lung Injury - USM Short Term Grant Scheme
2. Analysis of Pathophysiological Changes of the Airway Epithelium During Regeneration and Repair Following Tracheal Brushing in Rabbit - USM Short Term Grant Scheme
3. Preclinical Efficacy of Cell-Based Gene Transfer of Mesenchymal Stem Cells Overexpressing Angiopoietin-1 in an Experimental Model of Chronic Lung Disease - USM RU Grant Scheme
4. Understanding Transcriptomic Compositions Of Lung Cancer Stem Cell And The Effect Of Cancer Stem Cell In Lung Cancer Development And Progression Using Both In vivo And In vitro Model Systems - USM RU Grant Scheme
5. The Anti-senescence Effects of Mesenchymal Stem Cells (MSC)-Derived Extracellular Vesicles (Evs) on COPD - RU Top Down
6. Breast Cancer Translational Research Program at IPPT (BCTRP@IPPT) - RU Top Down
7. Celik Genetik, Terokai Stem Cell - Bahagian Jaringan Industri dan Masyarakat (BJIM) USM
8. Open Learning Space @ARASC atau Pusat Pengembangan Latihan Penternakan Komuniti B40 Sebagai Sumber Ekonomi Sampingan - Bahagian Jaringan Industri dan Masyarakat (BJIM) USM
9. Innovative trachea reconstruction: Long-term survival and regeneration following trasnplantation of mesenchymal stem cell infused 3D TechTra scaffold in large scale sheep transcheal transplant model - PRIME Grant Scheme
 
Number of Postgraduate Students Supervised: 
Program                                Status                  As a Chairman (Main Supervisor)                As a Member (Co-supervisor)
PhD                                       Graduated                       15                                                                      5
                                               Ongoing                           4                                                                       2                           
Masters (with thesis)             Graduated                         3                                                                       7
                                                Ongoing                           -                                                                       1
 
10. Experience as an External Examiner of PhD and Master’s Theses:
                  Thesis                                    No. of Students                       
                    PhD                                                9
                 Masters (with thesis)                       14
11. Achievements / Awards: 
                                                 Gold Medal (MTEX2024) - Main Inventor
                                                 Gold Medal (ITEX2023) - Main Inventor
                                                 Silver Medal (PECIPTA 2017) - co-inventor
                                                 Gold Medal (PECIPTA 2022) - co-inventor
                                                 Silver Medal (Innovations in Teaching & Learning Competition (INTELEC2023))
                                                 Excellence Service Award (2012, 2016, 2022)
12. Number of Publications:
                      Publication                       Quantity
                         Journal                                107
                         Book                                      2
                         H-Index (Scopus)                  25
                         Citation (Scopus)                 1973
13. List of 10 Significant Journal Publications (latest within 10 years):
       Indexed Journal (selected top published manuscripts)
          1. Tengfei C, Shiyu W, Longyu S, Lei C, Ni F, Yaoyu W, Jianing Z, Qing L, Kang L, Jie L, Yahaya BH, Lin J, Li W. S100A8 dysregulation as a neuroimmune nexus: Bridging childhood inflammatory infections to adult schizophrenia-like behaviors via the ELNI model. Schizophr Res. 2026 Feb;288:47-56. doi: 10.1016/j.schres.2025.12.016.
          2. Esmaeili S, Rahmati M, Salehi M, Yahaya BH, Zamani S. Enhancing Wound Healing with a Novel Alginate/Eggshell Membrane-Based Hydrogel Enriched with Red Ginseng Roots and Centella Asiatica. Skin Res Technol. 2026 Jan;32(1):e70325. doi: 10.1111/srt.70325.
         3. Yahaya BH, Bakar NFAA, Samat AA, Ishtiah AA, Yusof LM, Hamid ZAA, Osman ND, Khalil NA, Radzi RM, Musa MY, Jaafar M. Collagen-Coated 3D-TechTra Scaffold Integrated with Human Umbilical Cord Mesenchymal Stem Cells Enhances Tracheal Tissue Regeneration and Reduces Stenosis in Rabbit Models. Curr Med Sci. 2025 Oct;45(5):1123-1137. doi: 10.1007/s11596-025-00119-y.
         4. Zhang H, Feng T, Lin J, Yahaya BH. Bibliometric-driven research on chemoresistance in breast cancer: knowledge mapping, hotspot evolution, and emerging insights (1994-2024). Discov Oncol. 2025 Sep 3;16(1):1676. doi: 10.1007/s12672-025-03542-8.
         5. NR Jumat, MA Yunus, BH Yahaya, MY Aziz, MS Rofiee, R Mohamed (2025). Mesenchymal stem cell-macrophages influence cancer stemness and AKT1/YKL-39 expression in triple-negative breast cancer. Biomedical Research and Therapy 12 (8), 7650-7666
         6. Shuhaidatul Sarmiza Abdul Halim, N. ., Wisasi, M. ., Rungsisiwut, R. ., Mohamed, R. ., Shaharuddin, B. ., Suwan, N. ., Fitriyani Afiqah Abu Bakar, N. ., Ghozali, M. ., Atik, N., Rizky AA Syamsunarno, M. ., Supokawej, A. ., & Hisham Yahaya, B. . (2025). Revolutionizing Breast Cancer Treatment: The Role of Regenerative Medicine. Biomedical Research and Therapy, 12(6), 7489-7498. https://doi.org/10.15419/tjcsrg93
         7. Zhang S, Song H, Chang M, Lu Y, Liu S, Wu J, Liu Q, Pan Y, Du J, Yahaya BH, Liu Y, Lin J. MSC-EV-transmitted HSPA8 alleviates cisplatin-induced ovotoxicity by regulating the MGARP/PRDX2 axis. Int J Biol Macromol. 2025 Apr;304(Pt 2):140973. doi: 10.1016/j.ijbiomac.2025.140973
         8. Sun Y, Lu Y, Li X, He Y, Yong TK, Keng CS, Yahaya B, Liu Y, Lin J. Intelligent drugs based on notch protein remodeling: a defensive targeting strategy for tumor therapy. Cell Death Dis. 2024 Aug 28;15(8):632.
         9. Sun Y, Zhang W, Lu Y, He Y, Yahaya B, Liu Y, Lin J. An artificial signaling pathway primitive-based intelligent biomimetic nanoenzymes carrier platform for precise treatment of Her2 (+) tumors. Mater Today Bio. 2024 Jun 1;26:101105.
        10. Zhang H, Lin J, Yahaya BH. Comprehensive analysis of co-expressed genes with TDP-43: prognostic and therapeutic potential in lung adenocarcinoma. J Cancer Res Clin Oncol. 2024 Jan 28;150(2):44. 
         11. Anan A. Ishtiah, Omar Nafiis Hairuddin, Badrul Hisham Yahaya. Unlocking the Potential of 3D Spheroid Cultures in Breast Cancer Stem Cell Enrichment and Isolation. Eurasian Journal of Medicine and Oncology 2024, 8(3), 322–335.
         12. Zhang H, Hussin H, Hoh CC, Cheong SH, Lee WK, Yahaya BH. Big data in breast cancer: Towards precision treatment. Digit Health. 2024 Nov 3;10:20552076241293695. doi: 10.1177/20552076241293695. 
         13. Hairuddin, O., Yahaya, B., Ibahim, M., Verakumarasivam, A., Choy, C., Mazlan, M., Rahim, N., Dzulkarnain, S. M., & Mansor, S. (2023). Comparison of cancer stem cell enrichment between spheroids derived from single-cell and multicellular aggregate cultures. Biomedical Research and Therapy, 10(8), 5810-5830. https://doi.org/10.15419/bmrat.v10i8.823
         14. Zhang S, Yahaya BH, Pan Y, Liu Y, Lin J. Menstrual blood-derived endometrial stem cell, a unique and promising alternative in the stem cell-based therapy for chemotherapy-induced premature ovarian insufficiency. Stem Cell Res Ther. 2023 Nov 13;14(1):327.
         15. Zhang S, Liu Q, Chang M, Pan Y, Yahaya BH, Liu Y, Lin J. Chemotherapy impairs ovarian function through excessive ROS-induced ferroptosis. Cell Death Dis. 2023 May 24;14(5):340.
         16. Lian J, Zhu X, Du J, Huang B, Zhao F, Ma C, Guo R, Zhang Y, Ji L, Yahaya BH, Lin J. Extracellular vesicle-transmitted miR-671-5p alleviates lung inflammation and injury by regulating the AAK1/NF-κB axis. Mol Ther. 2023 May 3;31(5):1365-1382.
         17. Shaffi SC, Zakaria N, Halim NSSA, Ishtiah AA, Patar AA, Yahaya BH. The Rapid Development of Airway Organoids: A Direct Culture Strategy. Adv Exp Med Biol. 2023 Mar 30.
         18. Ridzuan, N., Zakaria, N., Widera, D. et al. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles ameliorate airway inflammation in a rat model of chronic obstructive pulmonary disease (COPD). Stem Cell Res Ther 12, 54 (2021).
         19. Halim, N.S.S., Ch’ng, E.S., Kardia, E. et al. Aerosolised Mesenchymal Stem Cells Expressing Angiopoietin-1 Enhances Airway Repair. Stem Cell Rev and Rep 15, 112–125 (2019).
         20. Halim NS, Aizat WM, Yahaya BH. The effect of mesenchymal stem cell-secreted factors on airway epithelial repair. Regen Med. 2019 Jan;14(1):15-31.
         21. Kardia E, Ch'ng ES, Yahaya BH. Aerosol-based airway epithelial cell delivery improves airway regeneration and repair. J Tissue Eng Regen Med. 2018 Feb;12(2):e995-e1007.
        22. Kardia, E., Mohamed, R. & Yahaya, B.H. Stimulatory Secretions of Airway Epithelial Cells Accelerate Early Repair of Tracheal Epithelium. Sci Rep 7, 11732 (2017).
        23. Gu Y, Lawrence T, Mohamed R, Liang Y, Yahaya BH. The emerging roles of interstitial macrophages in pulmonary fibrosis: A perspective from scRNA-seq analyses. Front Immunol. 2022 Sep 22;13:923235.
        24. Abdul Samat A, Abdul Hamid ZA, Jaafar M, Ong CC, Yahaya BH. Investigation of the In Vitro and In Vivo Biocompatibility of a Three-Dimensional Printed Thermoplastic Polyurethane/Polylactic Acid Blend for the Development of Tracheal Scaffolds. Bioengineering (Basel). 2023 Mar 23;10(4):394.
        25. Abdul Samat A, Abdul Hamid ZA, Jaafar M, Yahaya BH. Mechanical Properties and In Vitro Evaluation of Thermoplastic Polyurethane and Polylactic Acid Blend for Fabrication of 3D Filaments for Tracheal Tissue Engineering. Polymers (Basel). 2021 Sep 13;13(18):3087.
        26. Zakaria N, Mohd Yusoff N, Zakaria Z, Widera D, Yahaya BH. Inhibition of NF-κB Signaling Reduces the Stemness Characteristics of Lung Cancer Stem Cells. Front Oncol. 2018 May 17;8:166.
        27. Abdul Satar N, Ismail MN, Yahaya BH. Synergistic Roles of Curcumin in Sensitising the Cisplatin Effect on a Cancer Stem Cell-Like Population Derived from Non-Small Cell Lung Cancer Cell Lines. Molecules. 2021 Feb 18;26(4):1056.
        28. Zakaria N, Yusoff NM, Zakaria Z, Lim MN, Baharuddin PJ, Fakiruddin KS, Yahaya B. Human non-small cell lung cancer expresses putative cancer stem cell markers and exhibits the transcriptomic profile of multipotent cells. BMC Cancer. 2015 Feb 25;15:84
 
14. Book
       BH Yahaya (2022). Organoid technology for disease modelling and personalized treatment. Humana Press/Springer Nature
       Badrul Hisham Yahaya (2023): Mind Your Writing – I’m Your Thesis Examiner Penerbit USM
 
15. Chapter in Research Book
            1. BADRUL HISHAM YAHAYA* (2022). Ethical Implications on Organoid. In B. H. Yahaya (Ed.), Organoid Technology for Disease Modelling and Personalized Treatment (pp. 193-208). Cham: Springer International Publishing.
            2. BADRUL HISHAM YAHAYA* (2022). Biomaterials in Organoid Development. In B. H. Yahaya (Ed.), Organoid Technology for Disease Modelling and Personalized Treatment (pp. 155-178). Cham: Springer International Publishing.
            3. BADRUL HISHAM YAHAYA* (2022). Lung Organoid: Innovative Technology for Respiratory Disease Modelling. In B. H. Yahaya (Ed.), Organoid Technology for Disease Modelling and Personalized Treatment (pp. 55-70). Cham: Springer International Publishing.
            4. BADRUL HISHAM YAHAYA* (2021). Enhancement of Local Drug Delivery System Using Different Design of Gentamicin Loaded in Carbonate Apatite Scaffold. In M. T. Hameed Sultan, M. S. A. Majid, M. R. M. Jamir, A. I. Azmi, & N. Saba (Eds.), Biocomposite Materials: Design and Mechanical Properties Characterization (pp. 321-340). Singapore: Springer Singapore.
            5. BADRUL HISHAM YAHAYA* (2020). Acute Lung Injury: Disease Modelling and the Therapeutic Potential of Stem Cells. In K. Turksen (Ed.), Cell Biology and Translational Medicine, Volume 10: Stem Cells in Tissue Regeneration (pp. 149-166). Cham: Springer International Publishing.
            6. BADRUL HISHAM YAHAYA* (2019). Secretome of Mesenchymal Stem Cells and its Impact on Chronic Obstructive Pulmonary Disease. In P. V. Pham (Ed.), Stem Cell Transplantation for Autoimmune Diseases and Inflammation (pp. 139-157). Cham: Springer International Publishing.
            7. BADRUL HISHAM YAHAYA* (2019). Physico-Mechanical Properties of HA/TCP Pellets and Their 3D Biological Evaluation In-Vitro, in Tissue Engineering and Regenerative Medicine. Springer International Publishing.
            8. BADRUL HISHAM YAHAYA* (2018). The BRCA1 and BRCA2 genes in early onset breast cancer patients in Innovation in Cancer Research and Regenerative Medicine, Springer International Publishing.
 
Research Innovation
                      CytoQuick Gel Kit (Patent Filed) - TRL 5
                      3D-TechTra for Tracheal Scaffold (Patent Filed) - TRL 5
 
Academic Recognition & Leadership
                      Deputy Director (Research & Networks) – since Jan 2025 
                      Pusat Kanser Tun Abdullah Ahmad Badawi, Universiti Sains Malaysia
                      Director – Animal Research & Service Centre (ARASC) ( 2019 – 2021) Universiti Sains Malaysia
                      Visiting Professor (Since 2013 - present) – Xinxiang Medical University, Henan Province China
                      Head, Regenerative Medicine Cluster – Advanced Medical & Dental Insituite (AMDI), Universiti Sains Malaysia
                      Visiting Fellow (Oct 2021 - April 2022) – Department of Health, Faculty of Vocational Studies, Universitas Airlanggar,                                                                                                  Indonesia
                     Editor-in-Chief (former) – Journal of Biomedical and Clinical Sciences (JBCS)
                     Editor – Stem Cell Biology and Regenerative Medicine (Springer-Nature)
                     Series Editor – Tissue Engineering - Part A
                     Guest Editor – Frontiers in Cell and Developmental Biology
                     Associate Editors – Biomedical Research and Therapy (BMRAT)
                     Editorial board member – Majalah Kedokteran Bandung
                     Editorial Board Members – Stem Cells in Clinical Applications (Springer-Nature)
Committee
  • President, Malaysian Society for Stem cell Research & Therapy (MSCRT) (2026 – 2028)
  • Vice President, Malaysian Society for Stem cell Research & Therapy (MSCRT) (2024 – 2026)
  • Vice President, Tissue Engineering & Regenerative Medicine Society of Malaysia (former – for two terms)
  • Panel of National Institutes of Biotechnology Malaysia (NIBM) Animal Ethics Committee [NIBMAEC] (Since 2018 - present) 
  • Panel of USM Institutional Animal Care and Use Committee [USM IACUC] (Since 2018 - present) 
  • Academic Board Members of Institut Farmaseutikal Dan Nutraseutikal Malaysia [iPHARM] (Since 2022- present) 
  • USM Publication Committee 
  • Jawatankuasa Semakan Kriteria Kenaikan Pangkat Pegawai Sains (2025 – present)

 

Lecture Summary

 Precision oncotherapy demands more than tumour killing, it requires programmable selectivity that confines toxicity to malignant tissue while actively protecting organs vulnerable to treatment-related injury. This talk introduces the concept of “intelligent stem cells” as autonomous, logic-gated therapeutic platforms that couple tumour recognition to a predefined therapeutic output, enabling a shift from conventional “aggressive enrichment” strategies toward a defensive precision paradigm. At the core of this intelligence is a reconstructed Notch signalling architecture in which the extracellular recognition domain is redesigned to bind tumour antigens (e.g., Her2), while the intracellular module is replaced with synthetic transcriptional activators that trigger bespoke gene programs only upon contact-dependent receptor engagement. This physical-contact requirement functions as a biological “lock,” keeping engineered mesenchymal stem cells (MSCs) inert during transit through healthy organs. Two delivery modes exemplify this precision: (i) intelligent nanoenzyme carriers, where MSCs preloaded with Cu/Fe nanocrystal clusters initiate HSV-TK expression upon tumour contact and release their payload via ganciclovir-controlled rupture; and (ii) intelligent drug factories, where engineered MSCs synthesise and secrete anti-angiogenic biologics (e.g., endostatin) only at the lesion site, reducing off-target exposure and mitigating systemic complications such as cardiotoxicity. Precision oncotherapy must also preserve long-term quality of life by repairing collateral tissue damage. Here, MSC-derived extracellular vesicles (MSC-EVs) provide a complementary, cell-free reparative layer. Menstrual blood–derived MSC-EVs restore ovarian function after cisplatin injury by transferring HSPA8 to granulosa cells, upregulating MGARP, stabilising the antioxidant PRDX2, and reversing mitochondrial dysfunction and oxidative stress. Together, intelligent MSCs and MSC-EVs outline a dual strategy—tumour-locked therapy plus organ-preserving repair toward safer, truly precise oncotherapy.

References:

1. Zhang S, Yahaya BH, Pan Y, Liu Y, Lin J. Menstrual blood-derived endometrial stem cell, a unique and promising alternative in the stem cell-based therapy for chemotherapy-induced premature ovarian insufficiency. Stem Cell Res Ther. 2023 Nov 13;14(1):327. doi: 10.1186/s13287-023-03551-w.

 

2. Sun Y, Lu Y, Li X, He Y, Yong TK, Keng CS, Yahaya B, Liu Y, Lin J. Intelligent drugs based on notch protein remodeling: a defensive targeting strategy for tumor therapy. Cell Death Dis. 2024 Aug 28;15(8):632. doi: 10.1038/s41419-024-07008-7

 

3. Sun Y, Zhang W, Lu Y, He Y, Yahaya B, Liu Y, Lin J. An artificial signaling pathway primitive-based intelligent biomimetic nanoenzymes carrier platform for precise treatment of Her2 (+) tumors. Mater Today Bio. 2024 Jun 1;26:101105. doi: 10.1016/j.mtbio.2024.101105.

 

4. Zhang S, Song H, Chang M, Lu Y, Liu S, Wu J, Liu Q, Pan Y, Du J, Yahaya BH, Liu Y, Lin J. MSC-EV-transmitted HSPA8 alleviates cisplatin-induced ovotoxicity by regulating the MGARP/PRDX2 axis. Int J Biol Macromol. 2025 Apr;304(Pt 2):140973. doi: 10.1016/j.ijbiomac.2025.140973.

 


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